The Physiology and Mechanism of Growth

The Physiology and Mechanism of Growth

We present to you the third chapter of the N&G 2022 Yearbook!

Meet the authors, find out more about their topic and download the full book.

The Physiology and Mechanism of Growth


Primož Kotnik, Jarod Wong, and Moshe Phillip

Primož Kotnik
Jarod Wong
Jarod Wong
Dr Moshe Phillip
Moshe Phillip


In the present chapter, an international group of endocrinologists tried to select some of the most important articles dealing with the physiology of growth published in the period from July 1, 2020 to June 30, 2021. We specially looked for articles that shed more light on
the already known mechanisms related to linear growth and those dealing with the interaction between nutrition and growth.
We have tried our best to select some of the best manuscripts published in the specific period on this topic. We are aware of the possibility that we might have missed some other very important manuscripts, but hope that reading the chapter, the summary of the abstracts, and the comments of the authors will encourage the reader to explore the literature for more relevant publications.

Key Referenced Articles

Familial short stature – a novel phenotype of growth plate collagenopathies
Plachy L, Dusatkova P, Maratova K, Petruzelkova L, Elblova L, Kolouskova S, Snajderova M,
Obermannova B, Zemkova D, Sumnik Z, Lebl J, Pruhova S
J Clin Endocrinol Metab 2021;106:1742–1749
Assessment of longitudinal bone growth in osteogenesis imperfecta using metacarpophalangeal pattern profiles
Rauch D, Robinson ME, Seiltgens C, Sutton VR, Lee B, Glorieux, Rauch F
Bone 2020;140:115547
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate
Nishimori S, Wein MN, Kronenberg HM
Bone 2021;142:115709
Secondary ossification center induces and protects growth plate structure
Xie M, Gol’din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT, Kotova S, Shavkuta B,
Saxena A, Shumate LT, Metscher BD, Grosschmidt K, Nishimori S, Akovantseva A, Usanova AP,
Kurenkova AD, Kumar A, Arregui IL, Tafforeau P, Fried K, Carlstrom M, Simon A, Gasser C,
Kronenberg HM, Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A, Chagin AS
Elife 2020;9:e55212
Axial mechanical loading to ex vivo mouse long bone regulates endochondral ossification and endosteal mineralization through activation of the BMP-Smad pathway during postnatal growth
Miyamoto S, Yoshikawa H, Nakata
Bone Rep 2021;15:101088
H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair
Shao R, Zhang Z, Xu Z, Ouyang H, Wang L, Ouyang H, Greenblatt M, Chen X, Zou W
Bone Res 2021;9(1):30
Early detection of abnormal growth associated with juvenile acquired hypothyroidism
Saari A, Pokka J, Makitie O, Saha MT, Dunkel L, Sankilampi U
J Clin Endocrinol Metab 2021;106:e739-e748
Region-specific effects of blocking estrogen receptors on longitudinal bone growth
Jin LY, Lv ZD, Su XJ, Xu S, Liu HY, Li XF
J Endocrinol 2021;250:13–24
Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms
Sanchez-Garrido MA, Ruiz-Pino F, Pozo-Salas AI, Castellano JM, Vazquez MJ, Luque RM,
Tena-Sempere M
Sci Rep 2020;10:13898
Microbiomes and childhood malnutrition: what is the evidence?
McGuire MK, McGuire MA
Ann Nutr Metab 2021;77(suppl 3):36–48
Malnutrition and gut microbiota in children
Iddrisu I, Monteagudo-Mera A, Poveda C, Pyle S, Shahzad M, Andrews S, Walton GE
Nutrients 2021;13(8):2727
Maternal nutrient restriction in late pregnancy programs postnatal metabolism and
pituitary development in beef heifers
Long JM, Trubenbach LA, Hobbs KC, Poletti AE, Steinhauser CB, Pryor JH, Long CR, Wickersham TA,
Sawyer JE, Miller RK, Cardoso RC, Satterfield MC
PLoS One 2021;16:e0249924
Somatic growth in children with congenital heart disease at 10 years of age: risk factors and longitudinal growth Hapuoja L, Kretschmar O, Rousson V, Dave H, Naef N, Latal B
Early Hum Dev 2021;156:105349

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